I live in France and there are experts talking about the high mutability of Corona virus all the time.
Armando Arias, virologist at the University of Castilla-La Mancha in Spain and researcher on RNA viruses says:
« RNA viruses (Corona Virus) with smaller genomes, can tolerate higher mutation frequencies (the number of mutations relative to the total number of nucleotides). This number is about 1 mutation per 10,000 nucleotides, which in the world of biology is a lot »
"Large DNA viruses have much lower mutation rates (between 100 and 10,000 times lower). Because their genomes are so large, they can only tolerate one mutation per 10,000 nucleotides. There are many random mutations accumulated in a single genome, which could inactivate some vital functions for the virus. Therefore, DNA viruses are less mutable, "
Esteban Domingo, a virologist at the Severo Ochoa Molecular Biology Center in Madrid says:
« RNA viruses also have polymerases (the enzymes that copy genetic material) that mutate more than DNA viruses. And they have no error repair mechanism.RNA viruses multiply by making mistakes until they end up forming what the scientist calls "Mutants clouds”. »
Dale- I have found that a low percentage of the articles that I have read even address long Covid. Some that I have seen do refer to “mild” cases that do not require admission to the hospital, yet months on, people are seriously debilitated. Have you seen any statistics on how common this outcome is for mild or asymptomatic Covid infections? Anything on long Covid and contagion?
I live in France and there are experts talking about the high mutability of Corona virus all the time.
Armando Arias, virologist at the University of Castilla-La Mancha in Spain and researcher on RNA viruses says:
« RNA viruses (Corona Virus) with smaller genomes, can tolerate higher mutation frequencies (the number of mutations relative to the total number of nucleotides). This number is about 1 mutation per 10,000 nucleotides, which in the world of biology is a lot »
"Large DNA viruses have much lower mutation rates (between 100 and 10,000 times lower). Because their genomes are so large, they can only tolerate one mutation per 10,000 nucleotides. There are many random mutations accumulated in a single genome, which could inactivate some vital functions for the virus. Therefore, DNA viruses are less mutable, "
Esteban Domingo, a virologist at the Severo Ochoa Molecular Biology Center in Madrid says:
« RNA viruses also have polymerases (the enzymes that copy genetic material) that mutate more than DNA viruses. And they have no error repair mechanism.RNA viruses multiply by making mistakes until they end up forming what the scientist calls "Mutants clouds”. »
I’m confused about the virus mutability.
Can you help me to understand it?
Thanks
Eva
Dale- I have found that a low percentage of the articles that I have read even address long Covid. Some that I have seen do refer to “mild” cases that do not require admission to the hospital, yet months on, people are seriously debilitated. Have you seen any statistics on how common this outcome is for mild or asymptomatic Covid infections? Anything on long Covid and contagion?
John Pourchot