I read last winter that the Delta variant needs fewer ACE2 receptors and that is why it is infecting younger and older people. The older variant needed more. My school is about to make masks optional when students come back in 2 weeks. What can a person do to protect themselves. I plan to wear a mask and socially distance but how can one do this if our work environment does not require vaccine or masks?
A single viral particle has only ever needed a single ACE2 receptor to infect a host cell. The virus is a burglar, the ACE2 receptor is one of the doors on your house and the spike protein is the lockpick.
Imagine a burglar with a crappy lockpick. He might need to try a hundred doors before he can find one that'll open with his crummy lockpick.
Give that burglar a REALLY good lockpick and he only needs to try 2-3 doors before finding one he can open.
But he ONLY needs to open just one door...and he's inside your house. He doesn't need to lockpick every door on the house.
The Delta variant is the same old burglar (the SarsCoV2 virus), but is now equipped with a MUCH better lockpick (the mutated spike protein).
I wanted to ask you a question. I've been vaccinated once in May with the Pfizer-BionTech one. Couldn't take the second dose because of some issues. Now that everything got checked and cleared, I'm ready to take the second dose. Can I take the second dose 4 months after the first one? Any evidence on the later second dose?
I can't say enough how much I agree with you ,wondered what took you so long for those comments 😊,. Months the media pushed on the miracle vaccines, yet the thinking people were aware it's not as they say, not possible and there maybe side effects ,we did not have to hide it !! It would have been mire efficient to vaccinate more people sharing the truth or just saying "we don't know yet "
On other hand ,what do you think of this : Isreal reports 40 % of hospitalized are double vaccinated, country 75 % vaccinated ,similar to UK , however US keeps reporting "almost none 1-2 % of hospitalized are vaccinated, rate of vaccination here 50 %?? I worry that we are again trying to sugar coat it , but what do you think is going on ? Probably more virus,yes, probably waning immunity in elderly who got first vaccinated ? Another question ,why the nasal vaccines did not get a good financial support , I know of one in UOA that failed phase 1 trial, and some being developed on Spain , why we are not investing here ? Thank you again!!
Israel vaccinated first, thus it sees the vaccines waning first.
The UK stretched the second doses to 3 months after the first, so most people there are recently vaccinated and it is right now tearing through the young. Thus the low mortality (the long-term morbidity nobody wants to talk about).
In the US, the CDC is fudging data, plain and simple, just another in the long list of outright criminal acts that it has committed in the last 20 months,
Regarding the IM vs. IN vaccines -- last year the key objective was to declare victory over the virus as soon as possible and reopen the economy. Which in turn was so that the wealth redistribution (i.e. paying people to stay home and not work and various forms of debt cancellation) that would have had to happen if a proper containment programs was to be implemented could be avoided. And it had to be avoided at all costs from the perspective of our overlords, it threatened the very foundations of the current socioeconomic order.
This meant that the first vaccine out the gate would be the one they were going to stick with. And RNA vaccines you can develop very quickly, but they cannot be intranasal, they can be only intramuscular. And they were indeed the first to read out. Although the reality is that they rushed that too -- we should still have been in Phase III now in order to see how long protection lasts, and life would have been very different had that been the case, as it would have become apparent protection against variants is gone already by April with B.1.351 and P.1. Instead they declared complete success after 6-8 weeks of follow through.
The weird thing is that the vector vaccines could have been intranasal, after all it is an adenovirus that normally does exactly that -- infect our URT. And people have tested those as IN, with very promising results, yet there was this very weird insistence on injecting them into people's arms instead...
I read last winter that the Delta variant needs fewer ACE2 receptors and that is why it is infecting younger and older people. The older variant needed more. My school is about to make masks optional when students come back in 2 weeks. What can a person do to protect themselves. I plan to wear a mask and socially distance but how can one do this if our work environment does not require vaccine or masks?
That's a somewhat awkward way of describing it.
A single viral particle has only ever needed a single ACE2 receptor to infect a host cell. The virus is a burglar, the ACE2 receptor is one of the doors on your house and the spike protein is the lockpick.
Imagine a burglar with a crappy lockpick. He might need to try a hundred doors before he can find one that'll open with his crummy lockpick.
Give that burglar a REALLY good lockpick and he only needs to try 2-3 doors before finding one he can open.
But he ONLY needs to open just one door...and he's inside your house. He doesn't need to lockpick every door on the house.
The Delta variant is the same old burglar (the SarsCoV2 virus), but is now equipped with a MUCH better lockpick (the mutated spike protein).
Crimes against humanity and I will be sure your name gets to who it needs to.
Well, this article didn't age well. I wonder how many who read this article for guidance took the Jonestown Jab and died?
Dear Mr. Harrison,
I wanted to ask you a question. I've been vaccinated once in May with the Pfizer-BionTech one. Couldn't take the second dose because of some issues. Now that everything got checked and cleared, I'm ready to take the second dose. Can I take the second dose 4 months after the first one? Any evidence on the later second dose?
Hope to receive an answer.
Nice podcast from Israel
https://www.haaretz.com/amp/israel-news/.premium-israel-s-exhausted-hospitals-fear-wave-of-serious-covid-cases-1.10093177
I can't say enough how much I agree with you ,wondered what took you so long for those comments 😊,. Months the media pushed on the miracle vaccines, yet the thinking people were aware it's not as they say, not possible and there maybe side effects ,we did not have to hide it !! It would have been mire efficient to vaccinate more people sharing the truth or just saying "we don't know yet "
On other hand ,what do you think of this : Isreal reports 40 % of hospitalized are double vaccinated, country 75 % vaccinated ,similar to UK , however US keeps reporting "almost none 1-2 % of hospitalized are vaccinated, rate of vaccination here 50 %?? I worry that we are again trying to sugar coat it , but what do you think is going on ? Probably more virus,yes, probably waning immunity in elderly who got first vaccinated ? Another question ,why the nasal vaccines did not get a good financial support , I know of one in UOA that failed phase 1 trial, and some being developed on Spain , why we are not investing here ? Thank you again!!
Israel vaccinated first, thus it sees the vaccines waning first.
The UK stretched the second doses to 3 months after the first, so most people there are recently vaccinated and it is right now tearing through the young. Thus the low mortality (the long-term morbidity nobody wants to talk about).
In the US, the CDC is fudging data, plain and simple, just another in the long list of outright criminal acts that it has committed in the last 20 months,
Regarding the IM vs. IN vaccines -- last year the key objective was to declare victory over the virus as soon as possible and reopen the economy. Which in turn was so that the wealth redistribution (i.e. paying people to stay home and not work and various forms of debt cancellation) that would have had to happen if a proper containment programs was to be implemented could be avoided. And it had to be avoided at all costs from the perspective of our overlords, it threatened the very foundations of the current socioeconomic order.
This meant that the first vaccine out the gate would be the one they were going to stick with. And RNA vaccines you can develop very quickly, but they cannot be intranasal, they can be only intramuscular. And they were indeed the first to read out. Although the reality is that they rushed that too -- we should still have been in Phase III now in order to see how long protection lasts, and life would have been very different had that been the case, as it would have become apparent protection against variants is gone already by April with B.1.351 and P.1. Instead they declared complete success after 6-8 weeks of follow through.
The weird thing is that the vector vaccines could have been intranasal, after all it is an adenovirus that normally does exactly that -- infect our URT. And people have tested those as IN, with very promising results, yet there was this very weird insistence on injecting them into people's arms instead...
Sadly agree 100% thanks